مطالعه ی اثرات سم شناختی ناشی از مواجهه همزمان با صدا و تولوئن بر روی فاکتورها و پارامترهای باروری و بیوشیمیایی و هیستوپاتولوژیکی در خرگوش های سفید نیوزیلندی

مطالعه ی اثرات سم شناختی ناشی از مواجهه همزمان با صدا و تولوئن بر روی فاکتورها و پارامترهای باروری و بیوشیمیایی و هیستوپاتولوژیکی در خرگوش های سفید نیوزیلندی

نویسندگان مقاله پژوهشی: مهندس امیر رضا ابوئی مهریزی، مهندس شمس الدین ساعد موچشی، دکتر یحیی رسول زاده، دکتر احمد مهدی پور، مهندس فریبا ریحان محمد اوغلی، مهندس زینب ایرجی، دکتر علیرضا علی همتی ، مهندس مجید شکوهی

Toxicological Effects of Simultaneous Exposure to Toluene and Noise on some Sexual and Stress Parameters in New Zealand White Rabbits

Amirreza Abouee-Mehrizi 1,2,3 , Shamseddin Saed-Moocheshi 1,2,3,7 ,Yahya  Rasoulzadeh2*  , Ahmad Mehdipour 4 ,Fariba Mohammadoghli-Reyhan 2 , Zeynab Iraji 5 , Alireza Alihemmati 6 , Majid Shokoohi 6

1- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Occupational Health Engineering, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Occupational Health Engineering, Faculty of Public Health and Safety , Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
5- Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
6- Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
7- Department of Environmental Engineering, Faculty of Environment, University of Tehran, Iran

ABSTRACT:

Noise and toluene are among the numerous physical and chemical pollutants that can induce adverse effects on different body tissues and systems; nevertheless, most studies have only experimented the auditory changes induced by co-exposure to them. The present in-vivo study aimed to examine the endocrine effects of co-exposure to toluene and noise on the testes and adrenal glands. In this experimental study, 24 healthy male New Zealand White rabbits were used. The noise intensity was 100 dB (white noise) and the toluene concentration was 1000 ppm for two consecutive weeks. The lutein- izing hormone (LH), follicle-stimulating hormone (FSH), testosterone, cortisol and adrenocorticotropic hormone (ACTH) were measured using the enzyme-linked immu- nosorbent assay (ELISA) method.

The hematoxylin and eosin stain method (H&E) was performed for the histopathological analysis. Comparing different parameters in differ- ent groups on post-exposure days was carried out using GEE (generalized estimating equations) method. The results indicated that noise and toluene increased cortisol, LH and FSH levels during different days after the exposure. Exposure to toluene and noise made vacuolization and reduction of primary spermatogonial cells in the testes. More- over, lymphocyte infiltration, congestion, swelling and vacuolization were detected in adrenal glands through exposure to toluene and noise. Toluene and noise induced different destructive effects on the endocrine system. More studies are required to elu- cidate other endocrine changes induced by exposure to toluene and noise.

Keywords: Industrial mutagens Testis; Oxidative stress Adrenal glands; Sexual hormones

لینک دسترسی آنلاین به مقاله بصورت رایگان:

http://jpoll.ut.ac.ir/article_89731.html
http:/jpoll.ut.ac.ir/article_89731_839bd181efca45b8227da1d4373fd732.pdf https://jpoll.ut.ac.ir/article_89731_00d2421acf9128eab9344e67800a2cab.pdf